Some Pro and Anti-Inflammatory Cytokines in Children with Tonsillitis and their Correlations with Vitamin D Deficiency

نویسندگان

چکیده

Inflammation of the tonsils could be described as acute tonsillitis, mainly due to infection. Recurrent tonsillitis defined 3-7 episodes during first 3 years age. Vitamin D, which is a neuro-hormone with pleiotropic biological activities may modulate immune response by alleviation, and stimulation Th1 Th2 cell proliferation, respectively, that influence stimulation, synthesis, secretion both pro anti-inflammatory cytokines. In this study we aimed shed light on levels vitamin D in children different association interleukins (TNFα, IL-2, IL-4, IL-10). Blood samples were collected from 48 participants groups: control, (1-2 episodes/year), chronic (more than 7 serum was separated TNFα, IL-4 IL-10 estimated using ELISA technique. decreased significantly increased, level 16.38± 2.41ng/ml and, 14.13± 2.15 ng/ml compared control (30.91± 2.31 ng/ml), while pro-inflammatory cytokines (TNFα IL-2) increased (46.88± 14.05 44.55± 9.24, 1267.25± 111.85 1191.72± 121.52 ng/ml, respectively) (9.45 138.48 respectively). Anti-inflammatory (IL-4, IL-10) group (243.08± 28.72 24.27± 1.83 respectively), non-significantly (302.76± 38.93, 290.12± 44.69 28.16± 2.01, 26.29± 1.99 Significant direct correlation observed between (P<0.05). conclusion, deficiency affect number modulation some

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ژورنال

عنوان ژورنال: Iraqi Journal of Pharmaceutical Sciences

سال: 2022

ISSN: ['1683-3597', '2521-3512']

DOI: https://doi.org/10.31351/vol31iss1pp194-201